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KMID : 0389520140210010029
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Sleep Medicine.Psychophysiology
2014 Volume.21 No. 1 p.29 ~ p.32
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Insomnia in Relation to Suicide and Serotonin in Patients with Major Depressive Disorder
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Park Young-Min
Kang Seung-Gul
Lee Heon-Jeong
Kim Leen
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Abstract
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Objectives: The aim of current study is to evaluate the relationship between sleep, suicide and serotonin using some scales and loudness dependence of auditory evoked potentials (LDAEP).
Methods: Total 65 patients who met the criteria for major depressive disorder were enrolled in current study. The patients were divided into two subgroups according to their insomnia and a history of suicide attempts. The auditory event-related potentials were measured to evaluate LDAEP before beginning antidepressants.
Results: The scores of total Beck Depression Inventory (BDI) and BDI item 9 (suicide) were higher in insomnia subgroup than non-insomnia subgroup (respectively, p=0.0033 and p=0.03). However, LDAEP did not differ each other. The subgroup with a history of suicide attempts had a higher score of BDI item 9 than the subgroup without a history of suicide attempts (p=0.00012). There was a tendency for the LDAEP to be higher in the subgroup with a history of suicide attempts (1.39±0.94 μV) than the sub-group without a history of suicide attempts (1.05±0.75 μV), although the difference was not statistically significant (p=0.078).
Conclusion: Suicidality was related to insomnia. In addition, there was a tendency for serotonin activity to be lower in the subgroup with a history of suicide attempts. In future, more studies are needed.
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KEYWORD
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Insomnia, Suicide, Serotonin, LDAEP
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